Recognizing the Signs: Understanding Cushing’s Disease in Dogs

Cushing’s disease, also known as hyperadrenocorticism, is a hormonal disorder affecting middle-aged and senior dogs. It occurs when the body produces an excessive amount of cortisol, a hormone involved in stress response, blood sugar regulation, and immune function. While cortisol is vital, an imbalance can lead to a cascade of health complications. This article delves into Cushing’s disease in dogs, exploring its causes, symptoms, diagnosis methods, and empowering you to recognize the initial signs in your furry companion.

Understanding the Canine Body System: A Hormone Hierarchy

To understand Cushing’s disease, let’s explore the hormonal hierarchy within a dog’s body. The pituitary gland, located at the base of the brain, acts as a central control unit, secreting various hormones, including ACTH (adrenocorticotropic hormone). ACTH then stimulates the adrenal glands, situated on top of the kidneys, to produce cortisol. Cortisol plays a multifaceted role, regulating metabolism, blood sugar levels, and the immune system.

A Breakdown of Cushing’s Disease: Two Main Culprits

There are two primary causes of Cushing’s disease in dogs:

  1. Pituitary-Dependent Cushing’s Disease (PDH): This is the most common form, affecting roughly 80-90% of canine cases. A tumor on the pituitary gland causes it to overproduce ACTH, which in turn, stimulates the adrenal glands to churn out excessive cortisol.
  2. Adrenal-Dependent Cushing’s Disease (ADH): This less frequent form (around 10-15% of cases) arises from a tumor on one or both adrenal glands, causing them to directly overproduce cortisol, bypassing the normal regulatory pathway of the pituitary gland.

Identifying the Initial Signs of Cushing’s Disease in Dogs: When to be Alert

Cushing’s disease often develops gradually, and the initial signs might be subtle. However, vigilance can help detect the condition early on, allowing for prompt treatment and improved outcomes. Here’s a breakdown of some common warning signs:

  • Increased Thirst and Urination: One of the most prominent signs is excessive water consumption and urination. This occurs because the body attempts to flush out the extra cortisol through urine, leading to increased thirst to compensate for fluid loss.
  • Voracious Appetite and Weight Gain: Dogs with Cushing’s often experience increased hunger despite weight gain. This is because the elevated cortisol levels stimulate appetite, while simultaneously hindering the body’s ability to utilize energy from food effectively.
  • Lethargy and Weakness: The altered hormonal balance can lead to muscle weakness and fatigue, making even short walks seem daunting for your previously energetic companion.

Additional Signs to Watch Out For:

  • Hair Loss and Thinning Skin: The increased cortisol disrupts the normal hair growth cycle, resulting in hair loss and a dull, fragile coat.
  • Pot-Bellied Appearance: A distended abdomen, sometimes referred to as a “potbelly,” can occur due to muscle wasting and fat redistribution caused by hormonal changes.
  • Recurrent Skin Infections: The compromised immune system associated with Cushing’s disease makes dogs more susceptible to skin infections.

It’s important to note that these signs can also be indicative of other health conditions. If you observe any of these in your dog, consulting a veterinarian for a proper diagnosis is crucial.

The Impact of Cushing’s Disease: A Brief Overview

Left untreated, Cushing’s disease can have a significant impact on a dog’s health and well-being. Here’s a glimpse into some potential consequences:

  • Increased Susceptibility to Infections: The impaired immune system makes dogs more prone to bacterial and fungal infections.
  • Diabetes Mellitus: Cushing’s disease can disrupt blood sugar regulation, potentially leading to diabetes.
  • Muscle Wasting and Weakness: The disruption of protein synthesis caused by elevated cortisol levels can lead to muscle wasting and weakness.
  • High Blood Pressure: Cushing’s disease can contribute to high blood pressure, putting strain on the heart and circulatory system.
  • Liver and Kidney Problems: In severe cases, the altered hormonal balance can affect the liver and kidneys.

Diagnosing Cushing’s Disease in Dogs: A Multi-Step Approach

Diagnosing Cushing’s disease often involves a multi-step approach, as the initial signs can mimic other conditions. A veterinarian will typically consider your dog’s medical history, conduct a thorough physical examination, and recommend specific diagnostic tests. Here are some commonly used diagnostic techniques:

  • Blood Tests: Blood tests can evaluate overall health and assess for abnormalities suggestive of Cushing’s disease.
  • Urine Tests: Urine tests can measure cortisol levels and electrolyte imbalances.
  • Imaging Techniques: X-rays or abdominal ultrasound scans may be used to visualize the adrenal glands and check for enlargement.
  • ACTH Stimulation Test: This test measures the pituitary gland’s response to a synthetic ACTH injection. In dogs with PDH, the adrenal glands will overproduce cortisol in response to the stimulation.
  • Low-Dose Dexamethasone Suppression (LDDST): This test assesses the adrenal glands’ ability to suppress cortisol production in response to a low dose of dexamethasone, a synthetic glucocorticoid. In dogs with ADH, cortisol levels will not suppress adequately.

It’s important to remember that these tests should be interpreted by a veterinarian within the context of your dog’s individual case and medical history.

Frequently Asked Questions (FAQ) about Cushing’s Disease in Dogs

  • What are the treatment options for Cushing’s disease?

The treatment plan for Cushing’s disease depends on the underlying cause and severity. Common treatment options include surgery to remove a pituitary tumor (PDH), medication to suppress cortisol production, or radiation therapy to target the adrenal glands (ADH).

  • Is Cushing’s disease curable?

In some cases, particularly with PDH and successful surgical removal of the pituitary tumor, Cushing’s disease can be cured. However, in other cases, lifelong management with medication may be necessary.

  • What is the prognosis for dogs with Cushing’s disease?

Early diagnosis and treatment can significantly improve the prognosis for dogs with Cushing’s disease. With proper management, many dogs can live happy and fulfilling lives.

  • Are certain dog breeds more prone to Cushing’s disease?

Certain breeds, such as Poodles, Yorkshire Terriers, Boxers, Boston Terriers, and Dachshunds, seem to have a higher predisposition to Cushing’s disease.

  • How can I prevent Cushing’s disease in my dog?

Unfortunately, there’s no guaranteed way to prevent Cushing’s disease. However, maintaining a healthy weight for your dog and scheduling regular veterinary checkups can help with early detection and management.


Cushing’s disease, while a serious condition, can be effectively managed with veterinary guidance and early diagnosis. By understanding the signs, potential impacts, and diagnostic methods, you can be a vigilant pet parent and advocate for your dog’s health. Remember, early detection is key to a positive outcome. If you notice any of the signs mentioned in this article, consult your veterinarian promptly for a proper diagnosis and treatment plan.

Top Friendly Cats: Pawsitively Adorable Breeds That Form Purrfect Bonds

Hey there, fellow feline enthusiasts! 🐾 Are you ready to dive into a whisker-licking good time as we explore...

Exploring Big Bend, Texas With Dogs

<img class="dpsp-post-pinterest-image-hidden-inner dpsp-post-pinterest-image-hidden-single" src="data:;base64, Planning to visit Big Bend National Park with your dogs? You’ll need to plan ahead!...

Mega Pet: Your One-Stop Pet Paradise

Welcome to the pawsome world of Mega Pet! 🐾 If you're on the hunt for the ultimate pet haven,...

Embrace the Love: Pet Family

Hey there, fellow animal enthusiasts! Today, we're gonna dive into the heartwarming world of the Pet Family 🐾. Whether...

My Cat Has a Limp Tail, What’s Wrong? 5 Vet-Reviewed Possible Issues

Cats are expressive creatures, especially through their body language. Felines give many clues about their feelings and communicate widely...

Can I Carry My Cat in a Purse? Important Safety Tips

Getting your cat to and from the vet can be a difficult task if you don’t have a cat carrier. Some people opt...

What to Expect From Your Cat’s First Vet Visit: Complete Guide

Whether you’ve taken a pet to the vet before or not, it’s natural to have some questions about your cat or kitten’s first checkup....

Pet Remedy Kitten Calming Kit Review 2023: Pros, Cons, & Our Verdict

Our Final VerdictWe give Pet Remedy’s Kitten Calming Kit a rating of 4.75 out of 5 stars. Effectiveness: 4.5/5Uses: 5/5Ingredients: 4.75/5Scent: 5/5If you’re looking...

What to Expect on Your New Dog’s First Day Home?

By Savannah Admire Jayme Burrows / StocksyBringing a new dog...

The History of Commercial Pet Food: Invention & Timeline

Most cats and dogs today eat commercial pet food, but when was pet food invented, and at what point did it become popular? Dry...

How to Build a Cat Fort: 8 Fun & Easy Methods

Almost every child has built at least one fort during their childhood. Whether their fort is big or small, simple or complicated, it’s...

How to Prepare for an Animal Shelter Visit

By Savannah Admire PH888 /ShutterstockLooking at online listings for...

Why Is My Cat’s Third Eyelid Showing? 5 Vet Reviewed Reasons & Advice

Cats do not see the world in the same way that humans do. Their eye anatomy is different, and their eyes glow due to...

Can You Turn an Outdoor Cat Into an Indoor Cat? Facts & Tips

Cats instinctively like to be in nature, but the outdoors is not always the safest place for a cat to live. Many cats that...